Some risk factors have been reported to increase the risk of asthma, including soluble interleukin-6 receptor level (Rosa et al., 2019; Raita et al., 2021), childhood body mass index (BMI) (Au Yeung et al., 2021a), adult BMI (Granell et al., 2014; Skaaby et al., 2018; Xu et al., 2019; Sun et al., 2020; Au Yeung et al., 2021a), major depressive disorder (Mulugeta et al., 2020), early pubertal maturation (Chen et al., 2020), and age at puberty (Minelli et al., 2018). This evidence concerns the gene IL6R and major depressive disorder.