PRICKLE1 serves as a signaling factor in the non-canonical Wnt pathway, the disruption of which is known to cause cleft palate and to stunt limb growth (He and Chen, 2012; Mostowska et al., 2012; Yang et al., 2013; Liu et al., 2014; Gibbs et al., 2016; Wan et al., 2018). This evidence concerns the gene PRICKLE1 and cleft palate.