Based on RNAss (mRNA expression) and DNAss (DNA-methylation pattern), the four ferroptosis suppressor genes, ACSL3, CISD1, FANCD2, and SLC3A2, increased the tumor’s stem cell-like features, which indicated that the ferroptosis could cause tumor heterogeneity, leading to tumor progression in most cancer type (Figure 6C). This evidence concerns the gene CISD1 and cancer.