NFKB2 and common variable immunodeficiency: In addition, NFKB2 knockout mouse models as well as NFKB2 mutant, c.2854A>T (NFKB2Lym1/Lym1, nonsense mutation p.Tyr868*), demonstrate a CVID-like phenotype with hypogammaglobulinemia and poor humoral response to antigens (153).