C3 and complement 3 glomerulopathy: In a wider context, it would also be interesting to explore possible connections between the levels of C3d(g) dimers, their distribution in the body and pathological conditions associated with uncontrolled C3 activation, such as C3 glomerulopathy, as we surmise local upregulation of fluid phase C3d(g) concentrations is likely to enhance C3d(g) dimerisation.