Furthermore, when analyzing a previously published dataset (31) of circulating T cells from acute myeloid leukemia (AML) patients, a condition known to be associated with immune exhaustion (31, 52, 53), we noted high expression of transcripts encoding PD-1 along with p16INK4a, p21Cip1, and senescence-associated β-galactosidase (SA-β-Gal) (54) in T cells from patients relative to normal donors (Supplementary Figure 3). Here, CDKN2A is linked to acute myeloid leukemia.