PRKN and Parkinson disease: Here, we showed that heterozygous PRKN mutation carriers in the general population may self-report subtle motor signs (which can then be followed up by deeper phenotyping), have increased occurrence of diabetes, decreased heart rate, alterations of serum albumin and sodium, and increased NLR ratios, potentially further pointing to inflammatory activation as an early sign in the development of PRKN-related PD (46).