MID1 and diabetes mellitus: Because estimated glomerular filtration rate (eGFR) has been recommended as a marker for kidney dysfunction in diabetic patients by the American Diabetes Association and NIH (Dabla, 2010), so the expression of TRIM18 in renal tissues of control and DKD patients with different eGFR levels was measured and results indicated that TRIM18 expression was significantly increased along with the decrease of eGFR (Figure 1D).