Notably, some molecular channels are also related to protein kinase activation during PASMC proliferation under hypobaric hypoxia, as indicated by a study showing that transient receptor potential melastatin 7 (TRPM7), which acts as a magnesium channel in mammalian cells, is downregulated in PASMCs of patients with pulmonary hypertension and in rats with hypobaric hypoxia-induced pulmonary hypertension. The gene discussed is TRPM7; the disease is pulmonary arterial hypertension.