PTGS2 and pulmonary hypertension: As mentioned previously, YAP is a transcriptional regulator that, together with WW domain-containing transcription regulator 1 (WWTR1 or TAZ), contributes to PASMC proliferation and subsequent pulmonary hypertension under hypoxic conditions through inhibition of cyclooxygenase 2 (COX2) activity (Dieffenbach et al., 2017).