Interestingly, inhibition of the pathway involving the IL-6/sIL-6R complex reduces the pulmonary artery remodeling and pulmonary hypertension that occur under hypobaric hypoxia, highlighting that activation of the IL-6/sIL-6R complex enhances PASMC migration (but not proliferation) and that this migration process requires STAT3 activation and increases in [Ca2+]i (Maston et al., 2018). This evidence concerns the gene STAT3 and pulmonary hypertension.