JAK2 and Right ventricular hypertrophy: A recent study demonstrated that the JAK2/STAT3 pathway is involved in the proliferation of PASMCs under hypoxic conditions; additionally, mice with SMC-specific Jak2 knockout show reduced right ventricular systolic pressure and right ventricular hypertrophy under hypoxic conditions, implying improved function of pulmonary blood vessels (Zhang et al., 2020).