IL1B and Alzheimer disease: The interest in the role of immune processes in AD pathogenesis began with the discovery of major histocompatibility molecules and complement system proteins in amyloid plaques (Jonker et al., 1982), and the description of HLA-DR- and IL-1β-positive reactive microglia surrounding amyloid plaques and neurofibrillary tangles (McGeer et al., 1987, 1988).