Interestingly, a similar NGF dysmetabolism with increased cortical proNGF levels has been reported in DS (Iulita et al., 2014, 2016; Iulita and Cuello, 2016; Caraci et al., 2017), therefore providing an explanation for the cholinergic atrophy in DS (Yates et al., 1983; Kish et al., 1989; Lubec et al., 2001). Here, NGF is linked to Dravet syndrome.