Additionally, although PET tracers for Tau have proved a challenge for the field (Robertson et al., 2017), a recent study using the Tau PET tracer [18F]-AV1451 in a small cohort of DS individuals showed that Tau deposition was correlated with age, amyloid deposition, decreased brain volume and reduced glucose metabolism (Rafii et al., 2017). This evidence concerns the gene MAPT and Dravet syndrome.