LRRK2 and Parkinson disease: Our previous work has mechanistically linked depolarization-triggered Miro1 degradation and mitophagy to several PD-causing genes, including PINK1, Parkin, LRRK2, and SNCA (Wang et al., 2011; Hsieh et al., 2016, 2019; Shaltouki et al., 2018).