Although each individual variable alone including age, sex, Unified PD Rating Scale, Hoehn and Yahr Scale, and Mini-Mental Status Examination did not affect Miro1 ratio, there was a significant interaction between Hoehn and Yahr Scale and Mini-Mental Status Examination (Figures 3B–D, 4), suggesting that Miro1 ratio might respond to PD progression combined with cognitive impairment. The gene discussed is RHOT1; the disease is Cognitive impairment.