In fact, the only exceptions so far have been the aggravated/lethal colitides that take place in β-deficient IL-10−/− mice, a B-cell deficit (μMT/IL-10−/− cross)36, MAdCAM-1 blockade30, and in colitis-prone Gαi2 mice after treatment with anti-α4 integrin antibody37. The gene discussed is MADCAM1; the disease is colitis.