In addition, we calculated the relative intensity of PD-L1 expression on each cell type and found that the majority of PD-L1+ cells in each individual tumor expressing PD-L1 were CK− cells in the TME, with CD11c+ dendritic cells having the highest PD-L1 expression per cell despite being less prevalent than CD68+ macrophages (Supplementary Fig. 3g). This evidence concerns the gene CD274 and neoplasm.