When we compared average gene expression of responders vs. nonresponders in macrophages, monocytes, dendritic cells, and tumor cells we found that some of the most over-represented genes in responders were classical and non-classical MHC class I subunit genes H2-Q4, H2-Q6, H2-Q7, H2-K1, H2-D1, H2-T22, and H2-T23, and MHC class II subunit genes CD74, H2-Ab1, H2-Aa, and H2-Eb1, with tumor cells generally lacking class II expression (Fig. 6a). The gene discussed is CD74; the disease is neoplasm.