Given the known contributions of both CD4+ and CD8+ T cells to development of spontaneous diabetes in the NOD mouse, we hypothesized a concomitant and comparable increase in both CD4+ and CD8+ T cell infiltrate area in adult non-diabetic mice (13-weeks) relative to both young mice (4-weeks) and adult diabetic mice (17-weeks). The gene discussed is CD4; the disease is diabetes mellitus.