Progression to CRPC was also significantly associated with PC characteristics at initial diagnosis, PSA ≥ 18 ng/mL (HR, 2.519; 95% CI, 1.26–5.03; p, 0.009), GS ≥ 8 (HR, 2.173; 95% CI, 1.05–4.51; p, 0.037), high risk in National Comprehensive Cancer Network (NCCN)’s classification (HR, 2.173; 95% CI, 1.10–5.52; p, 0.028), metastasis (HR, 4.256; 95% CI, 2.38–7.60; p, < 0.001), and Stage IV (HR, 7.089; 95% CI, 3.56–14.1; p, < 0.001). The gene discussed is KLK3; the disease is pachyonychia congenita.