Blood biopsies compared to tissue biopsies at the same timepoint showed additional alterations, for instance, the ATR alteration present in the pretreatment blood but not the tumor biopsy sample of patient 6 (Fig. 3a; Supplementary Data 1), consistent with prior studies finding that blood biopsies better capture tumor heterogeneity across multiple sites38. The gene discussed is ATR; the disease is neoplasm.