Representative HE staining in xenograft tumor tissue (Fig. 6C), immunohistochemistry of Ki-67 (Fig. 6D), and a TUNEL assay (Fig. 6E) all indicate that in xenograft tumor tissue, cell proliferation is increased when miR-527 is inhibited and apoptosis is increased when hsa_circ_0003222 is inhibited. Here, MKI67 is linked to neoplasm.