Importantly, in contrast with the alterations occurred in MM tissue, the apoptosis of immune cells within spleen was inhibited by Reelin down-regulation, suggesting greater functional immune cells participated in immune response (apoptosis rate: LV3-Reln 14.33% ± 0.75% vs. LV3-NC 17.9% ± 0.66%, p < 0.01, Fig. 4C, E). This evidence concerns the gene RELN and Miyoshi myopathy.