EGF and cancer: Moreover, an unbiased analysis of the prognosis of various cancers according to SIRT7 mRNA level using a public online tool (https://kmplot.com/analysis) revealed that higher SIRT7 expression was associated with a good prognosis in cancers with EGF/Ras signaling-dependent progression, including bladder, breast, lung, pancreatic, and thyroid cancers and sarcoma (Supplementary Fig. 10a).