ACE2 and viral infectious disease: Nevertheless, current coronavirus-targeting antibodies focus mainly on highly conserved regions of RBD, such as S309,20 47D11,21 D405, G502, G504, and Y50.16 The epitope of 3E8 binding on ACE2 is only partially overlapping with that of RBD domain, but blocked virus infections with remarkable efficiency, demonstrating the extraordinary power of ACE2 targeting strategy.