The present study is the first to use big data from microarray analysis to demonstrate that the mRNA levels of multiple complements (C1qa, C1qb, C3) and complement receptors (C3aR1 and C5aR1) were upregulated in the glomeruli and renal tubules of patients with LN and the results were generally similar in the kidney tissues of NZB/W mice. This evidence concerns the gene C5AR1 and lobular neoplasia.