Neurogenesis-related genes such as DYRK1A and RCAN1, craniofacial defect-related genes such as DYRK1A, ETS2, and RCAN1, and tumor suppressor-related genes such as DYRK1A, ETS2, and RCAN1 were also reported in Down syndrome [26]. Here, DYRK1A is linked to Down syndrome.