The TNFAIP3/IFNGR1 region on chromosome 6 and the IFNAR1/IFNGR2 region on chromosome 21 interacted with genes encoding five subunits of the IFN I/III receptors in FLS (Fig. 5a,b), suggesting a close genetic link between FLS function and IFN response in RA. This evidence concerns the gene IFNAR1 and rheumatoid arthritis.