Similarly, soluble DNAM-1 (sDNAM-1) also inhibits the growth of cancer cell lines (K562 and HeLa cells) after binding CD155 or CD112 by enhancing NK cell cytotoxicity, and the inhibitory effect of DNAM-1 is significantly attenuated after DNAM-1 mAb blockade [62]. Here, PVR is linked to cancer.