Figure 5A shows that the DFNA5 expression level was significantly negatively correlated with the infiltration of lymphocytes in HNSCC, such as B cells (cor = − 0.223, P = 8.57e-07) and CD8 T cells (cor = − 0.223, P = 2.99e-07). This evidence concerns the gene CD8A and head and neck squamous cell carcinoma.