Similar pathogenic mechanism of cofilin-1-mediated modulation of sarcomeric actin dynamics may play a role in other muscular dystrophies, in which there appears to be abnormal activation of ERK1/2 signaling (Barton, 2006; Griffin et al., 2005; Kumar et al., 2004, 2011; Lang et al., 2004; Muchir et al., 2007; Smythe and Forwood, 2012). This evidence concerns the gene MAPK3 and muscular dystrophy.