ZEB1 promotes cancer stemness in glioblastoma (Rosmaninho et al., 2018; Siebzehnrubl et al., 2013), where it is part of an autoregulatory loop together with SOX2 and OLIG2 (Singh et al., 2017), two transcription factors with well-established functions in neural stem/progenitor cells (Ligon et al., 2007; Suh et al., 2007). Here, SOX2 is linked to glioblastoma.