Recent studies showed that ZEB1 functions in embryonic neurogenesis (Liu et al., 2019; Singh et al., 2016; Wang et al., 2019), and we previously found that ZEB1 is crucial for the self-renewal of glioblastoma cancer stem cells (Hoang-Minh et al., 2018; Jimenez-Pascual et al., 2019; Siebzehnrubl et al., 2013). This evidence concerns the gene ZEB1 and cancer.