Diarrhea in dogs, often associated with bacterial enteropathogens, is one of the most common clinical conditions encountered by veterinarians (Marks and Kather, 2003), and Shigella infection of mice lacking NAIP/NLRC4 in their intestinal epithelial cells induces a bacillary dysentery (Mitchell et al., 2020). Here, NLRC4 is linked to shigellosis.