As in the cancer tissue samples in TCGA, PDL1, HAVCR2, LAG3, PDL2, and TGFB1 expression significantly increase with age among GTEx normal samples pan-tissue, while JAK2 significantly decreases,andnosignificantchangeisidentifiedinCD86expression (p values and effect sizes are in Table S1). The gene discussed is LAG3; the disease is cancer.