For example, recent studies have shown that HOXB cluster genes can be classified as SEs in acute myeloid leukemia, and HOXB cluster gene expression is dependent on mutant NPM1 and its aberrant cytoplasmic localization.[22] Another study showed that a retinoid‐dependent cis‐regulatory element, distal element RARE,[23] determined HOXB cluster gene expression, and leukemic state. This evidence concerns the gene NPM1 and acute myeloid leukemia.