In the present study, our results demonstrated that elevated baseline serum Lp(a) was positively associated with angiographic progression of coronary artery disease, particularly in patients with relatively lower BMI, independent of traditional cardiovascular risk factors, including age, sex, BMI, history of HTN, DM, initially obstructive CAD, smoking status, HbA1c, FPG, non‐HDL, HDL‐C, LDL‐C, creatinine, UA and WBC. The gene discussed is LPA; the disease is coronary artery disorder.