However, the present study showed the association of baseline Lp(a) and CAD progression was more prominent in patients with relatively lower BMI rather than obesity, one possible explanation was that Lp(a) may play a significant role as an overlooked “residual risk factor,” which implying the importance of routine Lp(a) measurement to assist in early risk stratification in seemingly normal‐sized populations. Here, LPA is linked to obesity due to melanocortin 4 receptor deficiency.