HIV infection of early/mid-gestation HCs generated an overall robust type I IFN response, characterized by significant upregulation of the RLRs, STAT1, STAT5, and all the antiviral effectors tested (ISG15, OAS1, IFIT1, IFIT2, IFIT3, and Viperin) (Fig 6). The gene discussed is RSAD2; the disease is HIV infectious disease.