To characterize the type I and type III IFN response in placental HCs throughout pregnancy and following HIV infection, we measured mRNA concentrations of the RLRs (RIG-I, MDA-5, and LGP2) and key host antiviral effectors, including the signal transducer and activator of transcription (STAT) proteins by qRT-PCR. This evidence concerns the gene RIGI and HIV infectious disease.