HIV infection of early/mid-gestation HCs generated an overall robust type I IFN response, characterized by significant upregulation of the RLRs, STAT1, STAT5, and all the antiviral effectors tested (ISG15, OAS1, IFIT1, IFIT2, IFIT3, and Viperin) (Fig 6). This evidence concerns the gene IFIT3 and HIV infectious disease.