We also calculated differentially expressed genes (DEGs) in the three NK cell subclusters between the RA patient and HCs, and the results showed that some type I IFN- and IFN-γ-stimulated genes, such as STAT1 and SOCS1, were significantly upregulated in NK cell subclusters (Figure 3D–3G). The gene discussed is STAT1; the disease is rheumatoid arthritis.