Therefore, we hypothesized that exercise training might prevent hypertension-induced EndoG/AIF caspase-independent, Fas/FasL-mediated caspase-dependent and mitochondria-mediated caspase-dependent apoptotic pathways also aggrandized related Bcl-2 family and IGF-1 pro-survival pathways in the cerebral cortex. Here, IGF1 is linked to hypertensive disorder.