Taking our findings with the previously apoptotic theories together, we drew the hypothesized diagram (Figure 7) which suggested that cerebral cortex EndoG/AIF-related caspase-independent, Fas/FasL-mediated caspase-dependent and mitochondria-mediated caspase-dependent apoptotic pathways were augmented by early aged hypertension and were attenuated by exercise training. Here, FAS is linked to hypertensive disorder.