CASP8 and hypertensive disorder: 4) Exercise training reduced early aged hypertension hypertension-induced neural Fas/FasL-mediated caspase-dependent apoptotic pathway and the effect was confirmed by the reduction in expression levels of FasL, Fas, TNF-α, TNF receptor 1, FADD, active Caspase-8, and active Caspase-3 in the cerebral cortex.