This non-target tissue uptake not only impairs the detection of insulinomas but could also affect the localization of other GLP-1R positive tumors like pheochromocytomas and gastrinomas, due to the close local proximity of the kidneys to the respective target organs (pancreas (insulinoma), adrenal medulla (pheochromocytoma), duodenum, pancreas and periduodenal lymph nodes (gastrinoma)) (Luo et al., 2015; Sbardella & Grossman, 2020; Donow et al., 1991). The gene discussed is GLP1R; the disease is pancreatic insulinoma.