Different organs areinvolved in DM2 development, including pancreas (with loss of cell mass andfunction, impaired insulin secretion of beta cell and dysregulated glucagonsecretion by the alfa cell), liver (increased hepatic glucose output), skeletalmuscle (reduced peripheral glucose uptake and insulin resistance), kidneys(increased glucose reabsorption), brain (increased appetite and lack of satiety),small intestine (increased rate of glucose absorption), and adipose tissue (reducedperipheral glucose uptake and insulin resistance)2. The gene discussed is INS; the disease is Insulin resistance.