The results show that the experimental model using cafeteria diet associatedwith 35 mg/kg of STZ is a low-cost model and efficient in order to developDM2, confirmed by the presence of polydipsia, hyperglycemia, alteredbiochemical tests, insulin resistance and damages to the liver, pancreas andkidney, which is similar to the disease found in humans. The gene discussed is INS; the disease is Hyperglycemia.