Activation of MAPK ERK1/2 and JNK pathways is known to be involved in the development of insulin resistance and in the regulation of mitochondrial activity (Guebre-Egziabher et al., 2013; Wortzel and Seger, 2011; Zeke et al., 2016; Zhao et al., 2019). The gene discussed is MAPK8; the disease is Insulin resistance.