TGFB3 and Insulin resistance: Our lipidomic analysis indicated increased levels of palmitic acid, glycerophospholipids, sphingolipids including ceramide (42:1), diacylglycerol and medium-chain triglycerides in Tgfb3+/− kidneys, which are toxic intermediates that accumulate when β-oxidation is impaired and are also known to mediate insulin resistance and fibrosis.