Although early reports showed that B7‐H3 plays a costimulatory role in immune regulation and promotes the activation and proliferation of T cells through CD28 signaling [6, 7], subsequent studies also demonstrated that tumor‐expressing B7‐H3 functions as a cosuppressive molecule to inhibit T cell immune response, promote tumor proliferation and promote aggressiveness [8]. This evidence concerns the gene CD28 and neoplasm.