Expression of visfatin is found to be positively regulated in response to microbial stimulation by B cells, T cells, monocytes, macrophages, and neutrophils.7, 8, 9It has been reported that the expression of visfatin is upregulated in a variety of acute and chronic inflammatory diseases such as rheumatoid arthritis,10sepsis,11acute lung injury,12inflammatory bowel disease,13diabetes mellitus,14aging,15metabolic syndrome, and obesity,16nonalcoholic fatty liver disease,17where there is persistence of inflammation by inhibition of neutrophil apoptosis. Here, NAMPT is linked to obesity due to melanocortin 4 receptor deficiency.