FGFR3 and achondroplasia: Although it is a rare disorder with a prevalence of 15000 to 40000 live births, ACH is a very common bone dysplasia.2Majority of the ACH cases are sporadic.3The autosomal dominant inheritance is mainly caused by mutations offibroblast growth factor receptor 3(FGFR3) gene, which encodes a transmembrane (TM) receptor.FGFR3is important in development; therefore, the expression ofFGFR3has been reported in many tissues, including cartilage, brain, kidneys, and intestines.