Jane et al assessed the serum CIC levels in oral precancers and different grades of OSCC and found the mean levels of CIC were increased in OSMF when compared with oral leukoplakia, and it was also seen to be elevated in different stages of oral cancer group.1In contrast to the present study where elevated levels of CIC were found in precancer group compared with cancer group. Here, CIC is linked to lip and oral cavity carcinoma.