On comparison of three groups was done with respect to serum IgM, it was found that serum IgM level in oral precancer and cancer and oral precancer and controls were statistically significant were as comparison of oral cancer with control was not significant (Tables 1, 2, 3, 4,Figs. 1, 2, 3, 4). Here, CD40LG is linked to lip and oral cavity carcinoma.