GZMB and neoplasm: These include the GZMB gene, which encodes the granzyme B serine protease that is secreted by CD8+ T cells and NK cells and induces apoptosis in target cells binding to the corresponding receptor IGF2R. 77In line with our results, upregulation of the receptor on the membrane of tumor cells promotes penetration of granzyme B, favoring immune-cell-mediated apoptosis, and was suggested as a potential target for immunotherapy.78