ITGAL and cancer: Another important mechanism that we identified among the LR biomarkers is the stimulation of LFA-1 (encoded by ITGAL and ITGB2 genes) by ICAM (ICAM2 → ITGAL, ICAM1_ICAM3 → ITGAL, and ICAM3 → ITGB2 in 18, 11, and 8 cancer types, respectively).