Anakinra has been associated with drug-induced ILD andpulmonary fibrosis when used in patients with RA.[42] A severeinflammatory ILD associated with a high mortality has emergedin patients taking IL-1 and IL-6 inhibitors for the management ofsystemic juvenile idiopathic arthritis, suggesting a causal link withthese agents, although the exact relationship remains unknown.[43–45]. The gene discussed is IL1B; the disease is interstitial lung disease.