Rilonacept is a synthetic protein containing the extracellulardomains of IL-1R1 that behaves as a soluble decoy receptor for IL-1β,and binds with high affinity.[34] It is currently used for the treatmentof cryopyrin-associated periodic syndromes (CAPS) in adults andchildren 12 years and older. Here, IL1R1 is linked to cryopyrin-associated periodic syndrome.