Owing to the critical role TNF-α plays in the control of tuberculosis,the impact of its inhibition, particularly with the mAbs, on reactivationof tuberculosis is an important consideration.[17–18] TNF-α inhibitorshave been associated with increased susceptibility to tuberculosisinfection, poor granuloma formation, greater rates of tuberculosisreactivation and higher mortality from tuberculosis.[15,17,18] Screeningfor latent tuberculosis is recommended prior to initiating theseagents. The gene discussed is TNF; the disease is tuberculosis.