IL-1 does not refer to a single cytokine, but rather encompasses afamily of molecules, which have an important role in mediatingthe inflammatory response, including the induction of IL-6.[7,30]IL-1 cytokines are known to function as potent inflammatorymediators, and play a role in normal immune system function, andimmune-mediated disease, including cardiovascular, metabolic,neuro-degenerative and neoplastic diseases.[30] Of particularimportance is IL-1-beta (IL-1β), which is an important target forIL-1 antagonism.[31]. Here, IL1B is linked to neoplasm.