Although useful to control inflammation, these agents may be associated with druginduced lung disease, which may be difficult to differentiate from pulmonary disorders caused by the underlying autoimmune diseases.This review aims to provide a description of lung disease, both infectious and non-infectious, that may be induced by the administration ofbiologic anti-inflammatory agents with emphasis on inhibitors of tumour necrosis factor, interleukin-1, interleukin-6 and JAK. This evidence concerns the gene IL6 and autoimmune disease.