Contrarily, in PAIS, the clinical spectrum will depend on the residual activity of the androgen receptor, i.e., it can vary from a severe lack of virilization, expressed as almost female external genitalia, to an undervirilization that results in varying degrees of external genital masculinization, which typically presents with micropenis, hypospadias, and bifid scrotum with or without cryptorchidism [8]. This evidence concerns the gene AR and hypospadias.