BRD2 and major depressive disorder: Subsequently, in a 2003 study on women attending menopausal clinics, between the ages of 40 years and 55 years with depression, there was an observed association between the declining FSH levels and the declining Center for Epidemiologic Studies Depression (CES-D) scale scores over a six-week period. There was a proportionate association between the CES-D score and the FSH levels.