Research found that astrocytes also function to maintain the balance of BBB (blood-brain barrier)/BSCB (blood spinal cord barrier) and participate in various immune system reactions so that GFAP expression is considered a gliotic process due to inflammation or injury and GFAP can be markers of trauma and degenerative disease of the CNS [19]. The gene discussed is GFAP; the disease is neurodegenerative disease.