For example, miR-19a-3p was reported to promote the proliferation of hepatocellular carcinoma cells via regulation of the PIK3IP1/AKT pathway (30); however, another study reported that miR-19-3p induces colorectal cancer cell apoptosis by repressing the expression of Fas cell surface death receptor (31). This evidence concerns the gene PIK3IP1 and hepatocellular carcinoma.