Large-scale methylome data of HCC provided from the Cancer Genome Atlas Research Network clarified that downstream genes of the Wnt/β-catenin signaling pathway, such as LGR5, RNF43 and AXIN2, were demethylated at the promoter regions in CTNNB1-mutated HCC samples (Supplementary Table 3). Here, LGR5 is linked to hepatocellular carcinoma.