Among 114 cytokines registered in the CYTOKINE ACTIVITY gene set (M14581), 16 and 8 cytokines were remarkably downregulated in human and mouse CTNNB1Δex3 HCC cells, respectively (Fig. 4a and Supplementary Table 2a,b), and CCL20, CSF1, CXCL2 and GDF15 were commonly suppressed at the mRNA level (Fig. 4b), which was confirmed by quantitative RT-PCR analysis (Fig. 4c). The gene discussed is GDF15; the disease is hepatocellular carcinoma.