CTNNB1 and hepatocellular carcinoma: To determine major downstream genes of the Wnt/β-catenin signaling pathway in HCC, we compared gene expression profiles between human HCC samples with and without mutations in exon 3 of CTNNB1 by using public genome and transcriptome data sets provided from the Cancer Genome Atlas Research Network (TCGA) as shown in Supplementary Table 1.