CXCL2 and cancer: For examining the role of cytokines downregulated by β-catenin signaling activation, we generated the 3H3-Ctnnb1Δex3 cells ectopically expressing mouse Ccl20 and Cxcl2. Both Ccl20 and Cxcl2 overexpression in the 3H3-Ctnnb1Δex3 cells elicited 14.0% and 19.0% reduction of cancer cell viability compared with control cells, respectively, indicating that overexpression of the two candidate cytokines could show a rescue of T cell killing (Fig. 6e).