MC4R and hepatocellular carcinoma: Similarly to the human HCC cells, mouse HCC cells expressing active form β-catenin were derived from the 3H3 cell line, which was a HrasQ61L-mutated mouse HCC cell line isolated from the C57BL6/J MC4R-KO mouse model19, and then termed as 3H3-Ctnnb1Δex3.