HSP90B2P and spastic ataxia: Sacsin (SACS), a HSP gene associated with spastic ataxia (OMIM: #270,550)37,38, had four potentially damaging (ACMG category 1–3) missense variants in the Finnish exomes (rs192610957, rs144267558, rs116907814, and rs17325713) and two missense variants in the Danish exomes (rs147099630 and chr13:23915410G > A, p.H119Y).