In previously published work, we described a more direct link between obesity/dyslipidemia and breast cancer risk in studies, which demonstrated that 27HC, an oxysterol produced in a stoichiometric manner from cholesterol, functions as a bona fide endogenous estrogen and, as such, promotes the growth of ER-dependent cancers23. The gene discussed is ESR1; the disease is obesity due to melanocortin 4 receptor deficiency.