GPX4 and neoplasm: Interestingly, we have observed that knockdown of GPX4 inhibits the primary tumor growth only in 27HCR—but not 27HCS-B16F10 model (Supplementary Fig. 7d), suggesting that the metabolic reprogramming of tumor cells by chronic exposure to 27HC exposes a reliance on GPX4 as a vulnerability in both the primary tumors and in metastatic lesions.